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30. Comparative Analysis of Closed-Loop Ventilation Mode with Conventional Ventilation Modes in Intensive Care Unit Patients
Imran ul Haq1, Sadia Imran4, Usman ul Haq2, Muhammad Fareed Azam1, Verdah Sabih1 and Muhammad Ali3
ABSTRACT
Objective: To compare the number of manual adjustments and workload between closed-loop ventilation mode IntelliVent®-ASV and conventional synchronized intermittent mandatory ventilation mode in traumatic
brain injury.
Study Design: Randomized controlled trial study.
Place and Duration of Study: This study was conducted at the Intensive therapeutic care unit (ITC), POF Hospital, Wah Cantt. P. From November 2018 to April 2019.
Materials and Methods: Total of 100 patients with head injuries admitted in ITC, were selected through consecutive non-probability sampling and randomly allocated into two groups. group A receives closed-loop ventilation and group B synchronized intermittent mandatory ventilation. All ventilation parameters were recorded breath-by-breath and noted at 6 hours intervals and averaged over 48 hours. The number of manual adjustments assesses the workload for the healthcare team. Safety and efficacy were assessed by maintenance and fluctuations of EtCO2 and mortality outcomes.
Results: Number of manual ventilator setting changes required was lower in IntelliVent®-ASV as compared to the conventional ventilation group (7.46 ± 1.54 versus 12.84± 1.59) which was statistically significant (p-value 0.000). Mean EtCO2 reading among IntelliVent®-ASV Group and SIMV Group (35.58+2.12 Vs 33.26+1.48 respectively) shows that mean EtCO2 was better with IntelliVent®-ASV (p-value 0.000). Frequency and percentage of mortality were lower in the IntelliVent®-ASV Group compared to the SIMV group, 4(8%) Vs 12 (24%), which was statistically significant (p-value 0.029)
Conclusion: IntelliVent®-ASV required less manual intervention thereby reducing the workload in ICU.
Key Words: Close loop IntelliVent®-ASV mode, conventional ventilation mode, EtCO2.