1. Habib ur Rehman 2. Uzma Sarwar 3. Mansoor Majeed 

1 & 2. Asst. Profs. of Dermatology, Shalamar Medical & Dental College, Lahore 3. PG Trainee, DUHS, Karachi

ABSTRACT

Objective: To determine the efficacy and safety of low dose (20 mg) isotretinoin for the treatment of mild to moderate acne for a duration of six to nine months.

Study Design: This was an observational, non-comparative, uncontrolled study.

Place and Duration of Study: This study was carried out at the Department of Dermatology, Shalamar Hospital Lahore from 01-1-2010 to 31-12-2013.

Materials and Methods: Six hundred adult patients of either sex with mild to moderate acne and, ages between 15 to 25 years were enrolled. They were treated with a fixed low dose of isotretinoin daily irrespective of weight, for six to nine months. Patients were evaluated clinically at baseline, then monthly during the treatment and follow-up. Results: Of the 600 patients enrolled, 580 completed the study. 94% of patients were completely cured in six months with a cumulative dose of 62.37 mg/kg.Treatment was continuedfor 6 % of patients, who still had active acne lesions.The cure rate reached 98.96 % at the end of ninth months. Patients were followed for another six months and a relapse rate of 4.48% was observed. Mild cheilitis and xerosis were common. Laboratory abnormalities were mild and transient.

Conclusion: Six to nine months treatment with a daily dose of 20 mg/day isotretinoin was found to be effective in patients with mild to moderate acne. The drug was well-tolerated and showed almost negligible clinical and laboratory side effects.

Key Words: Acne, Low dose Isotretinoin, efficacy, side effects