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Abroo Fatima Qazi¹, Syna Pervaiz Singha², Maria Kazi³, Kamran Afzal⁴, Sayyada Humaira Masood⁵ and Alina Atif⁶

ABSTRACT

Objective: To evaluate the anti-diabetic effects of Omega-3-Fatty Acids on insulin resistance.

Study Design: Case control Study

Place and Duration of Study: This study was conducted at the jointly conducted at Isra University, Hyderabad and SAU, Tandojam from December 2016- December 2018.

Materials and Methods: 75 male albino Wistar rats were grouped (n =15 /group ) as negative control group A  and experimental groups as B, C, D and E. Group A & Group B (Diabetic control) received lab chow, while experimental streptozocin induced diabetic groups C,D and E received food supplemented with Omega-3-fatty acids with the different doses respectively for 90 days. All animals were euthanized by cervical dislocation. Blood samples were analyzed for blood glucose and serum insulin level to assess insulin resistance via HOMA-IR. Their pancreas was removed and weighed. The specimens were processed under light microscope using H & E stains.

Results: The administration of Omega-3-fatty acids, Blood glucose, serum insulin and HOMA-IR were observed to be normalized to almost normal and the pancreatic morphology of tissues showed significant improvement in the histological features at 03 different doses in the experiment groups. It is concluded that Omega-3-fatty acids ameliorated insulin resistance.

Conclusion: The present study found significantly favorable impact of O3FAs on insulin resistance with improved glycemic status, HOMA-IR and histologic features of pancreatic tissue at different doses and concludes that the use of Omega-3-Fatty Acids could be prescribed as supportive remedial treatment along with anti-diabetic medications.

Key Words: Diabetes mellitus, HOMA-IR, Insulin Resistance, O3FAs, Pancreas

Citation of article: Qazi AF, Singha SP, Kazi M, Afzal K, Masood SH, Atif A. Miraculous Therapy for Diabetes: Use of Omega-3-Fatty Acids. Med Forum 2023;34(3):40-44.