9. Mortality Associated with Isolated Pathogens in Neonatal Sepsis at Izzat Ali Shah Hospital, Wah Cantt
Shahzad Haider1, Sajid Nazir1, Khushboo Sehar1 and Munazza Saleem2
ABSTRACT
Objective: To analyse the mortality associated with isolated pathogens in neonatal sepsis in neonatal intensive care unit (NICU) at Izzat Ali Shah Hospital (IASH)
Study Design: A retrospective cohort study.
Place and Duration of Study: The study was conducted in NICU of IASH, Wah Cantt from 1st September 2016 to 31st December 2017.
Material and Methods: We analysed medical records of all the neonates admitted at Neonatal unit, IASH during study period. Records of patients with isolated pathogens on blood culture were included in study cohort. Outcome variable was mortality associated with isolated pathogens. Data including the gender, gestational age, place and mode of delivery, weight at birth and blood culture results were recorded against the outcome in the form of discharged home, died and transferred to other hospitals. Data was analysed by using SPSS version 19.
Results: Case records of 49 neonates were enrolled in the study, Overall mortality rate was 26%. Klebsiella (n=14) was the highest number of isolated pathogen followed by Acinetobacter and E-Coli. Mortality was highest with Methicilin resistant staphylococcus aureus (60%) followed by E-Coli (44.4%), Acinetobacter (23%) and Klebsiella (21%). Analysis of study cohort showed that 27 were males (55%) and 22 were females (45%) with mortality rate of 22% (15) and 31.8% (18) respectively. In study cohort 11 babies (22.4%) had gestational age<32 weeks with mortality rate of 45.5% (5) while in full term babies mortality reduced to 17.9%. Mortality in home delivered babies was 38.5%. Baby with vaginal delivery were 24 (42%) with 25% mortality. Among 25 neonates who were born by Caesarean section mortality rate was 28%. Two (66%) out of 3 neonates of less than 1000 gm died while 5 (25%) out of 22 babies of more than 2500 gm died during the admission.
Conclusion: The study concluded that mortality rate was higher in extreme preterm and very low birth weight babies with neonatal sepsis. Klebsiella has become the most common pathogen causing neonatal sepsis followed by Acinetobacter and E Coli. Highest mortality rate was observed with MRSA.
Key Words: Pathogens, Blood culture, Neonatal Sepsis
Citation of articles: Haider S, Nazir S, Sehar K, Saleem M. Mortality associated with Isolated Pathogens in Neonatal Sepsis at Izzat Ali Shah Hospital, Wah Cantt. Med Forum 2018;29(9):36-39.