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  3. 8.Efficacy of Racecadotril in Acute Watery Diarrhea as Compared to Placebo
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8.Efficacy of Racecadotril in Acute Watery Diarrhea as Compared to Placebo

Arshia Munir1, Kashif Ali2, Muhammad Bilal Khattak3, Muhammad Aqeel Khan4 and Faiqa Hashmat1

ABSTRACT

Objective: To determine the efficacy of racecadotril with placebo in patients presenting with acute diarrhea.

Study Design: Randomized Controlled Trial study

Place and Duration of Study: This study was conducted at the Department of Pediatric Medicine, Hayatabad Medical Complex, Peshawar from December, 2020 to June, 2021.

Materials and Methods: A total of 142 children of age 6 months to five years with acute watery diarrhea fulfilling the inclusion criteria were included in the study and randomly allocated in to two groups. Racecadotril was given to Group A patients while group B patients were subjected to placebo. The patients were followed to determine the efficacy in term of reduction of stool frequency and duration of diarrhea.

Results: The mean age was 3 ±1.5 years. The mean age of children in group A was 3 ± 1.5 years while in group B 2.9 ± 1.5 years (p 0.646). The percentage of male patients was 60.6% in group A and 49.3% in group B (p .177). The mean weight of the child in group A was 11 ± 4.7kg compared to 10.8 ±4.9kg (p 0.861). The mean duration of diarrhea in group A was 36.2 ± 7.92 hours compared to 36.1 ± 7.7 hours (0.0983). The mean baseline stool frequency was 4.9 ± 1.4 compared to 4.7±1.5 (0.536). Racecadotril was found more effective (80.3 %) than placebo (63.4%) group (0.025).

Conclusion: Racecadotril is has more encouraging results in the management of acute watery pediatric diarrheas under five years of age compared to placebo.

Key Words: Pediatric diarrhea, racecadotril, stool frequency, placebo

Citation of article: Munir A, Ali K, Khattak MB, Khan MA, Hashmat F. Efficacy of Racecadotril in Acute Watery Diarrhea as Compared to Placebo. Med Forum 2023;34(1):33-36.