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Inayatullah Memon and Attiya Memon

ABSTRACT

Objective: Determine the vitamin B₁₂ deficiency in megaloblastic anemia in rural population of Tando Muhammad Khan, Sindh

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the Pathology Department, Indus Medical College Hospital Tando Muhammad Khan from May 2017 to Feb. 2018.

Materials and Methods: A sample of 170 cases of megaloblastic anemia (75 male and 95 female were studied according to inclusion criteria. Volunteers were informed and asked for blood sampling. Blood samples were collected. Vitamin B₁₂ was detected by ELISA assay kit. Data was analyzed on SPSS (ver 22.0) at 95% CI (P ≤ 0.05).

Results: Mean vitamin B₁₂ deficiency was noted in both male and female subjects, however, the female subjects were having significantly low levels of 141.75±30.61 pg/ml in contrast to 201.16±36.7 pg/ml in male subjects (P=0.0001). Vitamin B₁₂ categorized as normal levels, borderline B₁₂ levels, deficient levels and severe deficiency levels were found in 40 (23.52%), 25 (14.70%), 87 (51.17%) and 18 (10.57%) respectively (P=0.0001). Total 130 (76.47%) subjects were having one or other type of vitamin B₁₂ deficiency.

Conclusion: Frequency of 76.47% of vitamin B₁₂ deficiency in megaloblastic anemia was noted in rural population of Tando Muhammad Khan, Sindh

Key Words: Vitamin B₁₂ deficiency, Megaloblastic anemia, Rural, Sindh

Citation of articles: Memon I, Memon A. Vitamin B₁₂ Deficiency in Megaloblastic Anemia in Rural Population of Tando Muhammad Khan, Sindh. Med Forum 2018;29(10):31-34.