1. Rabia Ghafoor 2. Bahram Khan Khoso 3. Sobia Fawad Hashmi

1. Senior Registrar of Dermatology, 2. Asstt. Prof. of Dermatology, RMO of Dermatology, Jinnah Postgraduate Medical Centre, Karachi

ABSTRACT

Objective: To observe the efficacy and adverse effect profile of Glucantime in treatment of cutanous leishmaniasis.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted in Dermatology Department, JPMC Karachi from  Jan 2007 to Jan 2015.

Materials and Methods: 252 patients of CL, diagnosed clinically and confirmed parasitologically were treated with injection glucantime. After taking history and physical examination, baseline complete blood count ,Liver function tests, Renal function tests and ECG were performed.76 patients were treated with intralesional injection and 156 patients were treated with intramuscular Glucantime. Treatment response was observed and adverse effects were noted. The data was recorded and analysed on SPSS version 16. Mean ±SD was calculated for continuous variables like age, duration of disease. Categorical values like gender, type, morphology, site of lesions efficacy and adverse effects were recorded as numbers and percentages.

Results: The mean age of I/L group was 31.4 ±11.6and for I/M group. Efficacy of Intramuscular Glucantime was 76.3% in intralesional group and 86.9%in intramuscular group. Adverse effects were seen in 25 % of intralesional and 26.9 %of intramuscular group.

Conclusion: Glucantime is effective and well tolerated drug in Old world CL both by intramuscular or intralesional route.

Key Words: Cutaneous Leishmaniasis, glucantime, interalesional, intramuscular, efficacy.

Citation of article: Ghafoor R, Khoso BK, Hashmi SF. Efficacy and Safety of Glucantime for Cutaneous

Leishmaniasis-Eight Years Experience at A Tertiary Care Hospital of Karachi. Med Forum 2015;26(7):27-30.