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7. Serum Selenium Levels: Correlation with Inflammatory Biomarkers and Oxidative Stress in Diabetic Nephropathy
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Original Article |
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Levels of Selenium in Patient with Diabetic Nephropathy |
Serum Selenium Levels: Correlation with Inflammatory Biomarkers and Oxidative Stress in Diabetic Nephropathy
Hanan M. Al-Nadawi and Waseem Yousif M Al-Dulaimy
ABSTRACT
Objective: To study levels of selenium in patient with diabetic nephropathy.
Study Design: Descriptive cross-sectional study.
Place and Duration of Study: This study was conducted at the Department of Chemistry and Baquba
General Hospital's Nephrology and Haemodialysis Unit in Ibn Sina Dialysis Centre from 20th October 2023 to
8th January 2024.
Methods: Eighty adults without a history of hematologic or oncologic disorders, malnutrition, or inflammatory disorders (acute or chronic) were identified in the first screening. We examined the hospital library to get the patients' ages, genders, treatment groups, and long-term conditions, such as cardiovascular disease, hypertension, congestive heart failure, arterial disease, and chronic obstructive pulmonary disease. Forty participants served as the control group for this study. They underwent a number of blood tests, including monitoring and recording of serum glucose, urea, creatinine, C-reactive protein, IL-6, glutathione peroxidase, and superoxide dismutase.
Results: Among people with diabetes, smoking was the leading cause of complications and 48 were heavy smokers. The risk of having renal failure increased with the duration of diabetes. Healthy people's urea and creatinine levels were much lower than those of diabetic patients with diabetic nephropathy.
Conclusion: The clear link between selenium, inflammation, and oxidative stress. Selenium was found to have a high positive link with IL-6 but no significant correlation with C-reactive protein. Selenium and glutathione peroxidase were found to have a weakly negative correlation.
Key Words: Diabetic patient, Diabetic nephropathy, Selenium, C-reactive protein, IL-6, glutathione peroxidase