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7. Role of Serum Procalcitonin in Sepsis

Haris Alvi, Muhammad Rehan and Abu Talib

 

ABSTRACT

 

Objective: Role of serum procalcitonin in sepsis

Study Design: Descriptive / Cross sectional study

 

Place and Duration of Study: This study was carried out at the Mamji Hospital Karachi from January 2013 to July 2014.

 

Materials and Methods: The adult patients presented with short duration of fever, altered consciousness, bed sores, cough, increased frequency of urine, diarrhea and vomiting and abdominal pain. ESR, CRP and serum procalcitonin level were sent simultaneously with blood, sputum and urine cultures. The study was conducted in Mamji Hospital F. B. area, data was recorded in a preset proforma. The features like biodata, symptoms/signs, biochemical test and cultures reports were shown in tables. The data was analysed on SPSS version 15.

 

Results: In this study total cases were 33. Males were 19(55%) and 14(45%)were females. The mean age was 47 +

 

19.  With the age range from 28 to 68 years. Males were slightly more than females. The patients were divided into two groups according to the level of procalcitonin. Group I were those with raised procalcitonin level > 0.5 and group II were those with procalcitonin level < 0.5. The ESR and CRP were raised in every case. In Group I total number of cases were 27, pneumonias 06 cases, UTI06 cases, bacterial meningitis 05 cases, bacterial dysentery 05 cases, skin infection 04 cases and septic arthritis 01 cases. In group II t tal cases were 06, 02 cases were viral one is cytomegalovirus and other is Epstein–Barr virus, 01 cases was connective tissue disease and was diaganosed as systemic lupus erythematosus 01 case was wegner’s granulomatosis, 01 case was bronchogenic carcinoma and 01 was peripartum cardiomyopathy. The culture report showed 08 cases were E coli, 6 cases were pseudomonas aeroginosa, 5 cases were staphylococcus aureus, 3 ases Enterobacter 03 cases and streptococcus pneumonia

 

2     cases.

Conclusion: In cases with fever the early detection of h gh serum procalcitonin level will clearly differentiate

between inflammatory conditions caused by bacterial rather   on ba terial conditions.

Key Words: procalcitonin, fever, sepsis, culture

 

Citation of article: Alvi H, Rehan M, Talib A. R le of Serum Procalcitonin in Sepsis. Med Forum 2016; 27(7):26-29.