Muhammad Wasif Iqbal and Zahid Ahmad

ABSTRACT

Objective: To observe the diagnostic accuracy of color Doppler ultrasound for diagnosing endometrial carcinoma (Ca) in Post-menopausal bleeding (PMB) women.

Study Design: Cross-sectional study

Place and Duration of Study: This study was conducted at the Department of Radiology Central Park Teaching Hospital Lahore during from June 2015 to Dec 2015.

Materials and Methods: One hundred and fifteen patients aged between 45 to 70 years having abnormal vaginal bleeding (postmenopausal bleeding) were included. After taking complete consent, patients detailed history age, gender, socio-economic status and previous hospital visited record was recorded. Endometrial thickness (ET), uterine artery resistive index (UARI) and results of Doppler ultrasound (DUS) were noted. Patients marked endometrial Ca whom ET was >5mm and UARI was <0.7. Histopathology results as a gold standard were also noted. The results of Doppler ultrasound were demonstrated with histopathology record.

Results: There were 20 (17.39%) patients were ages <50 years, 62 (53.91%) having ages of 50 to 59 years, and 33 (28.70%) patients were aged of > 59 years. 70 (60.87%) were resident of urban area while 45 (39.13%) having residency of rural area. 42% were literate and 58 % were illiterate, Diagnostic results of DUS were noted as 99 (86.07%) patients having endometrial Ca while 16 (13.91%) patients found no carcinoma of endometrial. Diagnostic results of US with histopathology findings were compared to each other, results were recorded True +ve, true –ve, false +ve, false-ve respectively as 99 (86.07%), 8 (6.96%), 6 (5.22%) and 2 (1.74%). We found sensitivity 98.02%, specificity 80%, PPV (positive predictive value) 94.29% and NPV (-ve predictive value) 80%.

Conclusion: It is concluded that performing DUS for diagnosing endometrial carcinoma in patients having postmenopausal/ vaginal bleeding was very effective with better specificity, sensitivity and positive and negative predictive values. We observe no complications/problems followed by the procedure.

Key Words: Postmenopausal bleeding, Endometrial carcinoma, Doppler ultrasound, Endometrial-thickness, Uterine artery resistive index

Citation of articles: Iqbal  MW, Ahmad Z. Determine the Diagnostic Accuracy of Color Doppler Ultrasound for Diagnosing of Endometrial Carcinoma in Post-menopausal Bleeding Women Taking Histopathology as