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7. Comparison of Montelukast with Fluticasone for Control of Asthma in Children

Rabia Saeed, Khadeeja Mustafa and Najam u Saqib

ABSTRACT

Objective: To compare the efficacy of Montelukast and Fluticasone for control of asthma among children of age 4- 10 years.

Study Design: A Randomized control trial study.

Place and Duration of Study: This study was conducted at the Department of Pediatrics Medicine Mayo Hospital Lahore from 12 January 2017 to 15 December 2017.

Materials and Methods: The ethical grant and informed consent was taken from Department of Pediatrics Medicine Mayo Hospital Lahore and parents before start of the study. The sample size of this study was 780 patients and they were randomized in two groups. Chi- square and student t test were used for categorical variables and pair t test was used to compare means. All the data was entered and analyzed by using the computer software SPSS version 21. In all the statistical interference, the p value of < 0.05 was considered as significant.    

Results: Overall, 780 patients were enrolled in this study and they were of both genders. The differences between both the groups were statistically insignificant except ASA (p=0.010) and operative time (p=0.000). The mean asthma RFDs and FEV1 before treatment in group “M” was 63.1±2.15 days and 2.5±1.23 liter respectively. While, the mean asthma RFDs and FEV1 before treatment in group “F” was 61.7±2.56 days and 2.0±1.35 liter respectively. The mean asthma RFDs and FEV1after treatment in group “M” was 133.50±4.59 days and 2.9±1.45 liter respectively. While, the mean asthma RFDs and FEV1 after treatment in group “F” was 138.5±4.67days and 3.1±1.12 liter respectively.

Conclusion: It has been concluded that Montelukast is not less effective than Fluticasone for asthma control among pediatric patients. Both the therapies of Fluticasone and Montelukast are well tolerated and can be used as first line drugs for asthma control.

Key Words: Montelukast, Fluticasone, Asthma, Pediatric patients.

Citation of articles: Saeed R, Mustafa K, Saqib N. Comparison of Montelukast with Fluticasone for Control

 

of Asthma in Children. Med Forum 2018;29(3):25-28.