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7. Comparison of Lung Function Changes Among Anemic and Non-Anemic Adults

Aliya Waseem1, Shahjabeen2, Syed Adnan Ahmed3, Saba Abrar3, Padma Rathore4 and Mohammad Saleh Soomro3

ABSTRACT

Objective: To find the correlation that exists between blood hemoglobin/ serum iron indices and lung function tests. To compare changes in lung functions amongst the anemic and non-anemic adults.

Study Design: Case control study.

Place and Duration of Study: This study was conducted at the Fatima Hospital, Baqai Medical University, Karachi and Abbasi Shaheed Hospital, Karachi from July 2017 to December 2017.

Materials and Methods: 100 males and 100 female diagnosed iron deficient anemic adults in range of 18-45 years and with no co-morbid respiratory and cardiac diseases were included. Inclusion criteria included iron deficient anemic adults with no acute emergency states and no chest and back area deformities. Blood samples were reanalyzed for blood hemoglobin (Hb) by automated cell analyzer and anemia were rechecked for confirmation of iron deficiency anemia (IDA) by doing further tests like serum iron, serum ferritin, serum Total Iron Binding Capacity (TIBC) levels by Enzyme Linked Immunosorbent Assay (ELISA). Digital spirometer was used to perform Pulmonary Function Tests (PFTs) which includes Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1st second of FVC (FEV1) in all anemic patients and lung functions were compared with lung functions of non-anemic healthy individuals.

Results: The FVC and FEV1 in male and female cases were significantly reduced(p<0.05) as compared to that in male and female controls respectively. Whereas the FEV1/FVC ratio was significantly increased (p<0.05) in male and female cases. Restrictive lung changes were observed in male and female cases.

Conclusion: In the present study positive association was observed between blood Hb/serum iron indices and lung functions in anemic patients. The results showed restrictive lung function changes in anemic subjects. While no abnormal lung function changes were found in non-anemic healthy participants.

Key Words: Hemoglobin, Iron Deficiency Anemia, Pulmonary Function Tests, Forced Vital Capacity, Forced Expiratory Volume in 1st second.

Citation of article: Waseem A, Shahjabeen, Ahmed SA, Abrar S, Rathore P, Soomro MS. Comparison of Lung Function Changes Among Anemic and Non-Anemic Adults. Med Forum 2020;31(11): 29-33.