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  3. 7. Antidiabetic Actions of Powdered Plant and Aqueous Extract of Allium Sativum (Garlic) Bulbs in Type-II Diabetic Patients
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7. Antidiabetic Actions of Powdered Plant and Aqueous Extract of Allium Sativum (Garlic) Bulbs in Type-II Diabetic Patients

1. Akbar Waheed 2. Usman Nawaz 3. G.A. Miana

1. Prof. of Pharmacology, AMC, Rawalpindi 2. PGR of Pharmacology, AMC, Rawalpindi

3. Rector ,Riphah Institute of Pharmaceutical Sciences, Islamabad

ABSTRACT

Objectives: To study hypoglycemic properties ofpowdered plant and aqueous extract of Allium sativum (Garlic) bulbs in type-II diabetics.

Study Design: Experimental human study.

Place and Duration of Study: This study was conducted at the Hamdard Institute of Pharmaceutical Sciences Islamabad and Army Medical College Rawalpindi from ___.

Material and Method: The study was performed on 45 humans, which were divided into 3 groups i.e. Group A, B and C. Group A comprises of 15 patients of type-II diabetes, taking no drugs for diabetes. Group B comprises of 15 patients of Type-II diabetes taking oral hypoglycemic agents with inadequate control of blood sugar levels. Group C was control group, containing 15 healthy volunteers. The study was divided into 2 phases. Initially, after baseline sampling for blood glucose and urinary glucose, all the subjects were given powdered bulbs of Allium sativum orally, at low (20 mg/kg/d), intermediate (30 mg/kg/d) and high (45 mg/kg/d) doses, for 14 days. At day 15, blood and urine sampling was done. After 1 week, all the subjects were administered aqueous extract of Allium sativumbulbs orally, at low (20 mg/kg/d), intermediate (30 mg/kg/d) and high (45 mg/kg/d) doses, for 14 days. At the end, sampling was done again.

Results: Both dry powdered plant and aqueous extract of bulbs of Allium sativum (Garlic) decrease blood and urine glucose levels in type-II diabetics, especially in the groups who were taking oral hypoglycemics and had inadequate control of blood glucose previously.

Conclusion: Allium sativum has significant hypoglycemic activity, particularly in high dose, and can be combined

 

with oral hypoglycemic agents in type-II diabetics.