6.Association of Age, Gender, and Duration of Illness with Hepatic Dysfunction in Patients with Malaria
Muhammad Saqib ur Rehman1, Adil Khan1, Ali Shan1, Jamal Ara2, Saleem Ullah Abro3 and Masooda Fatima1
ABSTRACT
Objective: To determine the association between age, gender, and duration of illness with hepatic dysfunction in patients with malaria.
Study Design: Observational / cross-sectional study
Place and Duration of Study: This study was conducted at the Department of Medicine in Baqai Medical University Fatima Hospital, Karachi from February to July 2021.
Materials and Methods: A non-probability consecutive sampling technique was used to collect data. A sample of 255 is taken by using Open Epi software with age of patient’s ranges from 25-65 years with either gender. Patients with having fever >1040F for more than four days with chills and rigors and positive Malarial parasite tests were included. Patients with liver cirrhosis, and unexplained hepatomegaly were excluded. The blood samples were collected and sent to the pathology laboratory for biochemical analysis. Data were entered and analyzed in SPSS version 16.0. Mean and standard deviations were calculated for the quantitative variables (like age of the patient and duration of illness). Frequencies and percentages were calculated for the qualitative variables (gender, age groups, duration categories, and hepatic dysfunction).
Results: A total of 255 diagnosed patients of malarial infection with a mean age of 38.87 ± 9.94 years were included. There were 185 (72.5%) males and 70 (27.5%) females. Hepatic dysfunction was found in 85 (33.3%) patients with malaria. Only duration of illness showed significant association (p<0.03) with hepatic dysfunction, while the different age groups, gender did not showed significant association.
Conclusion: In our study results, only duration of illness showed significant association (p<0.03) with hepatic dysfunction.
Key Words: Hepatic dysfunction, malaria, age
Citation of article: Rehman MS, Khan A, Shan A, Ara J, Abro S, Fatima M. Association of Age, Gender, and Duration of Illness with Hepatic Dysfunction in Patients with Malaria. Med Forum 2022;33(5):23-27.