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5.Evaluation of Left Atrial Volume and its Correlation to Left Ventricular Ejection Fraction in Hypertensive Patients

Samia Perwaiz Khan1, Safia Izhar2, Sahar Tariq3 and Shaista Kanwal2

ABSTRACT

Objective: Increase in left atrial size in patients with hypertension increases the risk of stroke, heart failure, morbidity and mortality. Aim of this study was to correlate the LAV to left ventricular function and effective antihypertensive therapy (ARB and thiazide diuretics) in hypertensive patients.

Study Design: Cross- sectional study

Place and Duration of Study: This study was conducted at the Cardiology OPD, Medicare Cardiac & General Hospital. Karachi, Pakistan from February 2021 to February 2022.

Materials and Methods: Five hundred   hypertensive patients, with uncontrolled blood pressure ≤140/90mm Hg and controls with blood pressure ≥120/80mm Hg on antihypertensive therapy were included in the study.  Echocardiography was performed (using GE-vivid S60), Measurements of LAV (normal range: 20-34mm/ ml2), left ventricular function and ejection fraction were also recorded.

Results: On echocardiography assessment, four hundred (80%) of these were on antihypertensive therapy with angiotensin receptor blockers (ARB) with or without hydrochlorothiazide and had satisfactory blood pressure control. One hundred (20%) were with uncontrolled hypertension. Fifty five (11%) of uncontrolled hypertensive patients had increased LAV (≥34 mm/ml2) and left ventricular dysfunction (systolic/diastolic) with reduced left ventricular ejection fraction ( 25-40).

Conclusion: This study concludes that echocardiography is a most convenient and non-invasive procedure to measure LAV, left ventricular dysfunction and ejection fraction in hypertensive patients. 2-Dimension and doppler echocardiography and can guide clinician for management of hypertension and prevention of cardiovascular complications.

Key Words: Resistant Hypertension, LAV (Left Atrial Volume), Left ventricular ejection fraction (LVEF), Angiotensin converting enzyme inhibitors (ARB), Left ventricular functions (LVF).

Citation of article: Khan SP, Izhar S, Tariq S, Kanwal S. Evaluation of Left Atrial Volume and its Correlation to Left Ventricular Ejection Fraction in Hypertensive Patients. Med Forum 2022;33(10):18-23.