Bahram Khan Khoso and Azam Jah Samdani
ABSTRACT
Objective: To evaluate the effectiveness of short contact 1.5% dithranol in the local population’s alopecia areata sufferers.
Study Design: Trial study
Place and Duration of Study: This study was conducted at the Karachi, Pakistan's leading tertiary care hospitals, Jinnah Postgraduate Medical Centre (JPMC) from October, 2021 to August, 2022.
Materials and Methods: Twenty (20) patients were enlisted from the dermatology department of one of Karachi, Pakistan's tertiary care hospitals (JPMC) after receiving ethical approval, and they received treatment with 1.5% dithranol. Short demographic information and the mean SALT score were recorded. Total duration of therapy was 8 months. The effectiveness of the treatment was evaluated together with the hair regrowth score.
Results: There were 8/20 (40%) females and 12/20 (60%) men, ranging in age from 18 to 50 (Mean=29.75 ±10.19 years), with an illness duration of 1 to 12 months (Mean=5.05 ±3.02 months). Mean Salt score was 2.7±0. At 3, 6, and 8 months, the mean scores for hair regrow were 1.3±1.03, 1.9±1.12, and 2.1±1.25, respectively. However, 25% of patients had partial hair growth at 3 months. Treatment effectiveness was 15% after three months, 30% after six months, and 45% after eight months, respectively
Conclusion: For longer treatment periods, topical brief contact 1.5% dithranol's effectiveness was found to improve. Yet, to determine the effectiveness of treatment, lengthy therapy and extensive comparison studies more accurately are required.
Key Words: Alopecia areata, Dithranol, Efficacy, Short Contact
Citation of article: Khoso BK, Samdani AJ. Efficacy of Short Contact 1.5% Dithranol Therapy in Mild to Moderate Alopecia Areata in Patients Reporting to Tertiary Care Hospital Karachi. Med Forum 2023;34(3):22-26.
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