1. Farah Asad 2. Fatima Rizvi 3. Jawed Iqbal

1,2. Asstt. Profs. of Pharmacology & Therapeutic, JM&DC, Karachi  

3. M.Phil Student, Dept. of Pathology, BMSI, JPMC, Karachi

ABSTRACT

Objective: To evaluate the efficacy and safety of 5% permethrin in scabies patients

Background: Scabies is a contagious, itchy ectoparasitic infection. It is a common public health problem with an estimated global prevalence of 300 to 400 million cases. They increases day by day.5%permethrin is one of the effective treatment of scabies, it is highly effective, well tolerated, poorly absorbed and rapidly metabolized by skin.  

Study Design: Open label clinical trial

Place and Duration of Study: This study conducted in Basic Medical Sciences Institute with collaboration of Dermatology Department from ___.

Materials and Methods: This study sample involved 65 clinically diagnosed scabies patients one was lost from follow up, the duration of study was 90 days. They were treated with 5% permethrin cream, clinical data was collected by using questionnaire. Patients were divided into three age groups and given two applications of permethrin cream on first and 15 day. Follow up was done on Day 3, Day 15, Day 30 and Day 90 

Results: It was found that efficacy and safety of permethrin cream in scabies patients was highly significant which clinically improved the symptoms of patients.

Conclusion: Scabies patients should advised 5% Permethrin cream with conventional therapy which improves symptoms significantly following proper local.

Key Words: Scabies, 5% Permethrin Cream, Efficacy And Safety.