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5. A Prospective Study on Efficacy of Bevacizumab for Retinal Vein Occlusion
Ali Afzal Bodla and Muhammad Afzal Bodla
ABSTRACT
Objective: To evaluate the efficacy of intravitreal Bevacizumab for branch retinal vein occlusion and central retinal vein occlusion.
Study Design: A prospective, non-randomized interventional trial.
Place and Duration of Study: This study was conducted at the Eye Department, Multan Medical and Dental College in collaboration with Bodla Eye Care, Multan from June 2014 till May 2016.
Materials and Methods: This study was conducted on patients who presented with central or branch retinal vein occlusion. They had intravitreal bevacizumab in operating room settings.
Results: A total of 43 patients were recruited in the study starting from June 2014 till May 2016. 21 were diagnosed to have Branch Retinal Vein Occlusion BRVO and 22 had Central Retinal Vein Occlusion CRVO. Drop outs (lost to follow up) were excluded from the study. Patients were followed for twelve months. By the end BRVO patients improved a mean of 9.7 (p<0.05) ETDRS letters, while CRVO improved by a mean of 1.6 letters (p=0.50). The percentage of patients who lost >15 ETDRS letters were 45.4%. in CRVO group, while 9.5% in BRVO group, A reduction of mean central macular thickness was noted in both groups over a period of twelve months. In CRVO group mean reduction was 231 microns (p<0.001) in CRVO and 214 microns (p<0.001) in BRVO group. However it was noticed that anatomical reduction in foveal thickness did not translated into improvement in visual acuity.
Conclusion: Our study looked at the effect of Bevacizumab in clinical practice on retinal vein occlusion. There was significant improvement in BRVO group in terms of visual acuity as well as reduction in CMT central macular thickness. In CRVO group, however Bevacizumab failed to show any significant improvement in terms of improvement in visual acuity despite of clinically significant reduction in macular thickness. Key Words: Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion, Bevacizumab.
Citation of article: Bodla AA, Bodla MA. A Prospective Study on efficacy of Bevacizumab for Retinal Vein Occlusion. Med Forum 2017;28(6):17-20.