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5. A Comparative Analysis of Lithium Induced Cerebellar Cortical Toxicity in Albino Rats

1.  Tazeen Kohari 2. Khalid Sayeed

 

1.  Asstt. Prof. of Anatomy, 2. Asstt. Prof. of Physiology, Liaquat College of Medicine and Dentistry, Karachi

 

ABSTRACT

 

Objective: To compare the thickness of cerebello cortical gray matter of albino rats after chronic ingestion of Lithium carbonate.

 

Study Design: Prospective experimental study

 

Place and Duration of Study: This study was carried out in Animal House affiliated with atomy department BMSI, JPMC, Karachi from April 2012 to June 2012.

 

Materials and Methods: Thirty male albino rats of 100-200 grams were selected and divided into two major groups A and B. Each major group consisted of 15 animals and my study was conducted according to the time period of the study which was 2 weeks, 6 weeks and 12 weeks. The control group purpose was served by Group A which was given lab diet and B was the Lithium treated group. Lithium carbonate (ADAMJEE PHARMACEUTICALS) was given at a dose of 20mg/kg/day for 2, 6 and 12 weeks. Cerebellar Gray matter thickness was measured at 2nd, 6th and 12th weeks in the normal healthy control group and Lithium treated group.

Results: Group B showed a progressive decrement of gray matter as the time   eri d of study advance.

 

Conclusion: The present study concluded that Lithium carbonate causes a significant decrease of cerebello cortical gray matter.

 

Key Words: cerebellum, Lithium carbonate, Gray matter.

 

Citation of article: Kohari T, Sayeed K. A Comparative Analysis of Lithium Induced Cerebellar Cortical Toxicity in Albino Rats. Med Forum 2016;27(3):17-20.