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  3. 4.Diagnostic Accuracy of Thrombocytopenia and Fib 4 Score in Predicting Esophageal Varices Using Endoscopy as Gold Standard Among Patients with Chronic Liver Disease
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4.Diagnostic Accuracy of Thrombocytopenia and Fib 4 Score in Predicting Esophageal Varices Using Endoscopy as Gold Standard Among Patients with Chronic Liver Disease

Muhammad Affan Qaiser1, Nazish Butt2, Fariha Anjum3, Mashal Fatima4, Ayman Fiaz4 and Iqra Hafeez4

ABSTRACT

Objective: To assess diagnostic accuracy of thrombocytopenia and Fib 4 Score in predicting esophageal varices using endoscopy as gold standard among patients with chronic liver disease.

Study Design: Descriptive cross sectional study.

Place and Duration of Study: This study was conducted at the Study was conducted at advanced GI & Liver Tower, hospital, Multan, from 15-09–2022 to 15-06-2023.

Methods: A total of 377 patients with chronic liver disease aged between 20-60 years were included. Three ml of venous blood sample was drawn and sent to the Central laboratory of the hospital for platelet count and other biochemical tests. The FIB-4 score was calculated for all patients and endoscopy was carried out for all enrolled patients to visualize esophageal varices.

Results: Mean age of these patients with CLD was 46.20±7.80 years (range; 33 years to 60 years) and 232 (61.5%) were male patients. Grade 1 esophageal varices were noted in 67 (17.8%), grade 2 in 181 (48.0%), grade 3 in 40 (10.6%). Sensitivity of thrombocytopenia was 38.89%, Specificity  was 75.53%, PPV was 84.85%, NPV was 28.16% and Diagnostic Accuracy was 48.01%. For FIB score >3, Sensitivity was 34.03%, Specificity was 78.65%, PPV was 83.76%, NPV was 26.92% and Diagnostic Accuracy was 44.56%.

Conclusion: Thrombocytopenia and FIB score >3 revealed good diagnostic accuracy in predicting esophageal varices in CLD patients. These are simple tests which can be easily employed by treating physicians to anticipate disease severity in these patients.

Key Words: Chronic Liver disease, Diagnostic Accuracy, Esophageal varices, Endoscopy.

Citation of article: Qaiser MA, Butt N, Anjum F, Fatima M, Fiaz A, Hafeez I. Diagnostic Accuracy of Thrombocytopenia and Fib 4 Score in Predicting Esophageal Varices Using Endoscopy as Gold Standard Among Patients with Chronic Liver Disease. Med Forum 2023;34(10):18-22. doi:10.60110/medforum.341004.