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44.Antibiotic Sensitivity Pattern in Blood Culture Positive Typhoid Fever

Ammara Manzoor1, Syeda Tahira Batool1, Toqeer Ahmed2 and Jawad Khalid3

ABSTRACT

Objective: To assess the antibiogram assay for the typhoid culture positive samples

Study Design: A observational study

Place and Duration of Study: This study was conducted at the Pediatric Department of Divisional Headquarters Teaching Hospital, Mirpur, Azad Kashmir from April 2022 to April 2023.

Materials and Methods: All the patients from both in and outdoor were enrolled in our study. The Kirby-Bauer disk diffusion technique was used to assess the antibiotic susceptibility of Salmonella isolates by using Mueller-Hinton agar. All the analysis of data was done by employing IBM SPSS version 24.

Results: In our study, a total of 180 children participated. The male children were 99 (55%) whereas female children were 81 (45%). Amongst the salmonella spp isolates, sensitive cases of typhoid were 16 (29.63%); cases of MDR 35 (66.67%), whereas cases of XDR were 3(5.56%). Amongst the 54 isolates of salmonella spp, 11 (20.37%) isolates were sensitive to Ampicillin while 43 (79.63%) isolates were resistant. 9 (16.67%) isolates were sensitive to Chloramphenicol whereas 45 (83.33%) isolates were resistant. Ceftriaxone was sensitive in 22 (40.74%) isolates while 32 (59.26%) isolates were resistant to Ceftriaxone. Ciprofloxacin was sensitive in 18 (33.33%) isolates while it was resistant in 36 (66.67%) isolates. Amongst the 54 isolates, Azithromycin was sensitive in 52 (96.30%) isolates while it was resistant in 2 (3.70%) isolates. Meropenem was the most efficient antibiotic in the current study. All the isolates 100% (n=54) were sensitive to Meropenem.

Conclusion: Our study concludes that meropenem and azithromycin are the most sensitive antibiotics against the Salmonella spp isolates. Enteric fever MDR and XDR strains are becoming more prevalent, and they have very high resistance to the most widely used antibiotics. The usage of antibiotics without prescription must be avoided, and prescribing procedures must be changed.

Key Words: Antibiotic sensitivity pattern; Blood culture; Typhoid fever

Citation of article: Manzoor A, Batool ST, Ahmed T, Khalid J. Antibiotic Sensitivity Pattern in Blood Culture Positive Typhoid Fever. Med Forum 2023;34(7):188-192. doi:10.60110/medforum.340744.