Search Submit Your Manuscript

Become A Member

  1. Home
  2. Novemeber 2024
  3. 42. Biochemical Mechanisms of Hypertension and Their Implications for Public Health Interventions in Mirpur, AJK
Article Image
Admin

42. Biochemical Mechanisms of Hypertension and Their Implications for Public Health Interventions in Mirpur, AJK

Original Article

Biochemical Mechanisms of Hypertension and Their Implications

Biochemical Mechanisms of Hypertension and Their Implications for Public Health Interventions in Mirpur, AJK

Saeed Ahmed1, Alyia Imtiaz4, Farooq Ahmed Noor2 and Amna Ahmed Noor3

ABSTRACT

Objective: To investigate the biochemical mechanisms of hypertension and evaluate their implications for public health interventions aimed at controlling and preventing hypertension in Mirpur, AJK.

Study Design: cross-sectional study

Place and Duration of Study: This study was conducted at the Department Of   Community   Medicine  &  Medicine  of  DHQ Hospital & Medical College,  Mirpur AJK from 10th   June 2023  to 20th  May  2024.

Methods: A cross-sectional study was conducted systematically, involving 300 adults from Mirpur, AJK, aged 35-65 years. Biochemical testing was performed thoroughly to assess markers such as blood lipid profiles, inflammatory cytokines, renin-angiotensin-aldosterone system (RAAS) activity, and endothelial function. Data on lifestyle factors, such as diet, physical activity, and smoking habits, were also collected comprehensively. Statistical analyses, including correlation and regression, were employed rigorously to identify key biochemical factors associated with hypertension and evaluate their impact on public health interventions.

Results: Significant correlations were found strongly between hypertension and elevated levels of inflammatory markers (C-reactive protein: r=0.59, p<0.001) and RAAS activity (plasma renin levels: r=0.48, p<0.01). Lifestyle factors, particularly poor dietary habits and low physical activity, were also found to exacerbate hypertension considerably. Public health interventions focusing on dietary improvements, increased physical activity, and stress management were associated significantly with a reduction in blood pressure levels (mean reduction: 10 mmHg systolic, 7.2 mmHg diastolic, p<0.001).

Conclusion: The biochemical mechanisms of hypertension, including inflammation and RAAS dysfunction, are recognized critically as playing a crucial role in its development and progression. The importance of tailored public health strategies in managing hypertension at the community level was emphasized strongly.

Key Words: Hypertension, biochemical mechanisms, public health interventions

Citation of article: Ahmed S, Imtiaz A, Noor FA, Noor AA. Biochemical Mechanisms of Hypertension and Their Implications for Public Health Interventions in Mirpur, AJK. Med Forum 2024;35(11): 194-197. doi:10.60110/medforum.351142.