1. Muhammad Shahzad Farooq 2. Bushra Shaheen 3. Mahmood Asif 4. Arif Malik

1. Asstt. Prof. of Biochemistry, PMC, Faisalabad 2. Asstt. Prof. of Biochemistry, IMC, Faisalabad

3. Demonstrator of Physiology, PMC, Fsd 4. Assoc. Prof of Biochemistry, IMBB, University of Lahore, Lahore

ABSTRACT

Objective: This study was aimed to evaluate the effects of subclinical hypothyroidism on lipid profile with special reference to total cholesterol and triglyceride levels. 

Study Design: Analytic study 

Place and Duration Study: This study was carried out at the Punjab Institute of Nuclear Medicine (PINUM), Faisalabad and IMBB, university of Lahore from January 2011 to September 2011. (Eight months)  

Materials and Methods: 100 female patients of age ranges from 20-50 years having subclinical hypothyroidism (SCH) and 20 euthyroidsubject  of same age and sex (control) were included in this study. Serum FT ₄, FT₃, TSH, total cholesterol and triglyceride of subclinical hypothyroid patients and control group were determined.  Result: In subclinical hypothyroid patients total cholesterol were significantly increased as compared to euthyroid group. Serum TSH and total cholesterol showed positive correlation. Serum triglyceride did not significantly increased in SCH. 

Conclusion: The total cholesterol level elevated in SCH. This increases the risk of atherosclerotic coronary artery disease (CAD) in subclinical hypothyroid patients.

Key Words: Subclinical hypothyroidism (SCH), Free thyroxine (FT₄), Free triiodothyronine ( FT₃), Thyroid stimulating hormone (TSH), Cholesterol, Triglyceride

Citation of article: Farooq MS, Shaheen B, Asif M, Malik A. Evaluation of Serum Triglyceride and Cholesterol in Subclinical Hypothyroidism. Med Forum 2015;26(1):13-17.