4. Anti-Hypertensive Potentiating Effects of Simvastatin on Amlodipine
Wajid Ali, Afsheen Siddiqi and Khadija Imran
ABSTRACT
Objective: To determine the In vivo vasodilatory effect of simvastatin (Statin) in the presence of Amlodipine(Calcium Channel Blocker).
Study Design: Experimental animal study on rats
Place and Duration of Study: This study was conducted at the Department of Pharmacology, Ayub Medical College, Abbottabad from May 2015 to June 2016
Material and Methods: Hypertension was induced in rats by giving Depomedral TM injection subcutaneously (20mg/kg) of body weight for 1 week. For antihypertensive activity single dose follow up regimen of test drugs were used. Fluctuations in systolic blood pressure (SBP) was calculated using Non Invasive Blood Pressure (NIBP) System of power lab using rat tail cuff method.
Results: Our study showed significant results for lowering of systolic blood pressure in rats receiving Amlodipine alone and then Simvastatin in the presence of Amlodipine.
Conclusion: This study demonstrates thatSimvastatin and Amlodipine when used in combination have potentiating or additive vasodilatory effects resulting in lowering of systolic blood pressure.
Key Words: Simvastatin. Amlodipine, systolic blood pressure (SBP), Cardiovascular diseases(CVDs)
Citation of articles: Ali W, Siddiqi A, Imran K.. Anti-hypertensive Potentiating Effects of Simvastatin on Amlodipine. Med Forum 2018;29(10):14-17.