3.Prognostic Significance of Biochemical and Hematological Features with Ca125 in Newly Diagnosed Patients of Ovarian Cancer
Shahida Parveen1, Rubaida Mehmood2 and Kainat Warraich1
ABSTRACT
Objective: To investigate the significance of biochemical and hematological features with Ca125 in newly diagnosed patients of ovarian cancer.
Study Design: A prospective study
Place and Duration of Study: This study was conducted at the Multan Institute of Nuclear Medicine and Radiotherapy (MINAR) from July 2018 to September 2019 for a period of one and a half year.
Materials and Methods: One hundred females patients with age ranging from 18 to >56 years with persistent malignant ovary tumor (untreated) were involved in this study. All biochemical tests were performed in (MINAR) lab. SPSS version 24.0 was used for data analysis. One way ANOVA test was used to investigate the variation among the groups (age & stage). Associations of Ca125 with CBC, LFT and RFT were assessed by Spearman correlation before checking the Normality or Normal distribution by D’Agostino test. The level of statistical significance was set at p<0.05.
Results: Overall results showed the strong negative association of creatinine (r=-0.47, p=0.01) and positive association of eosinophil(r=0.40, p=0.03) with CA125, while in age group-II positive association of PLT (r=0.62, p=0.01) with CA125 was calculated. In epithelial ovarian cancer there observed a significant negative association of Ca125 with MCV (r=-0.48, p=0.02) and also in seniors (age group-III, r=-0.76, p=0.03). Negative association of Ca125 was observed with RDWCV (r=-0.89, p=0.02) in stage-I, in stage-III negative association with MCV(r=0.66, p=0.02) while in stage-IV RBC indices RBC (r=0.76, p=0.01), HGB (r=0.67, p=0.03) and HCT (r=0.72, p=0.02) showed significant positive association with CA125.
Conclusion: Ca125 correlates with MCV in untreated epithelial ovarian cancer at senior age group and has no association in germ cell carcinoma. MCV and RDW-CV should be considered important diagnostic and prognostic factor in different stages of ovarian cancers.
Key Words: Bio-chemical parameters, Ca125, Hematological parameters, Prognostic factor, RDW-CV.
Citation of article: Parveen S, Mehmood R, Warraich K. Prognostic Significance of Biochemical and Hematological Features with Ca125 in Newly Diagnosed Patients