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Anosha Afzal¹, Jehan Alam¹, Raja Muhammad Daniyal¹, Noshaba Rahat², Samreena¹ and Zulakha Akhtar¹

ABSTRACT

Objective: To evaluate the histopathological grading of oral squamous cell carcinoma in patients at the time of presentation on biopsy.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the Oral & Maxillofacial Surgery Department of Jinnah Postgraduate Medical Center, Karachi from 17^th June 2022 to 30^th November 2022.

Materials and Methods: A total of 212 patients were enrolled in study diagnosed cases of squamous cell carcinoma on biopsy were evaluated for histopathologic features. Main variables of study were Age, gender, lesion site and histopathologic grading. SPSS version 24 was used for data analysis. Frequency and means were calculated categorical and numerical variables respectively. P value less than or equal to 0.05 was considered as significant.

Results: The average age of the patients was 51.66±12.19 years. Most of the patients 49.1% were having age between 41-60 years of age group. Buccal mucosa was the most common site in the study patients as 72.6% followed by tongue 17.5%, lower lip 8.0%, hard palate 1.9%. According to histopathological grading, the 97 (45.7%) patients had well differentiated. Only 2.4% patients were diagnosed with undifferentiated OSCC. Buccal mucosa site was highly associated with histopathological grading, (p<0.001).

Conclusion: Histopathology is useful diagnostic tool for oral squamous cell carcinoma, most of cases in this study were found well differentiated with buccal mucosa as common site of lesion. Male gender and middle age of 20-40 years are more prone to OSCC.

Key Words: Oral squamous cell carcinoma, Histopathology, Biopsy, Tertiary care hospital, Site of lesion

Citation of article: Afzal A, Alam J, Daniyal RM, Rahat N, Samreena, Akhtar Z. Histopathological Grading of Squamous Cell Carcinoma at Time of Presentation in Tertiary Care Hospital. Med Forum 2023;34(1):
12-15.