35.Influence of Celecoxib on Serum Urea Alongwith Favorable Effects of Lycopene on Albino Rats; An Investigational Study
Sadia Sundus1, Ashok Kumar3, Ata-ur-Rehman5, Neelam Mallick2, Muhammad Imran2 and Ali Nawaz Bijarani4
ABSTRACT
Objective: To evaluate the influence of celecoxib on serum urea along with enhancement by lycopene.
Study Design: Investigational Study
Place and Duration of Study: This study was conducted at the Animal House of BMSI, JPMC, Karachi from May, 4th May 2016 to 3rd June 2016.
Materials and Methods: Physically fit forty adult male Albino rats of 200-220gm and 90-120 days old were taken for this study and distributed into 4 groups, control group was chosen as Group1A, In Group 1B Celecoxib was given 50 mg/kg orally, In Group 1C Celecoxib was given 50 mg/kg with lycopene50 mg/kg orally and In Group 1D lycopene was given 50 mg/kg orally for 30 days. At accomplishment of study, animals were sacrifice and tissues were preserved for staining.
Results: In Group 1B serum urea was markedly raised, however serum level were amended in Group 1c which were given celecoxib with lycopene.
Conclusion: This study reveals that lycopene amended the serum deviations of Group 1B.
Key Words: Celebrex, nephroprotective, chemoprotective, PGE
Citation of article: Sundus S, Kumar A, Ata-ur-Rehman, Mallick N, Imran M, Bijarani AN. Influence of Celecoxib on Serum Urea Alongwith Favorable Effects of Lycopene on Albino Rats; An Investigational Study. Med Forum 2021;32(10):159-161.