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  3. 35.Antibiotic Resistance Profile of Helicobacter Pylori Isolates from Dyspeptic Patients of Civil Hospital, Khairpur
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35.Antibiotic Resistance Profile of Helicobacter Pylori Isolates from Dyspeptic Patients of Civil Hospital, Khairpur

Shehzad Tariq1, Farukh Imtiaz1, Tabish Akbar3, Bakhtiar Ahmed4, Sarmad Saeed2 and Bakhat Ali Ansari5

ABSTRACT

Objective: To examine the frequency of H. pylori in patients with dyspepsia and also to test the antibiotic susceptibility profile of isolates.

Study Design: Cross sectional study

Place and Duration of Study: This study was conducted at the Department of Microbiology, Shah Abdul Latif University, Khairpur for one year from 01-Jan-2019 to 31-12-2019.

Materials and Methods: Biopsy specimen from 100 patients with dyspepsia from both sexes was collected from civil hospital, Khairpur. After culturing the samples in Microbiology Institute, Shah Abdul Latif University, Khairpur, the identification of the samples was carried out (gram staining, catalase, oxidase and urease). The susceptibility profile to ten common antibiotics was tested by Disk diffusion method.

Results: From total 100 subjects, 100 biopsy samples from were collected. Mean age of the patients in years were 40±15.4. Out of 100 biopsies, 30 were positive for H. pylori. From these positive samples, majority of 56.7% were isolated from males and 43.3% from females. Out of 30 isolates, 11.7% isolates were sensitive and 88.3% showed intermediate resistance.  From 30 isolates, 4.7% isolates were sensitive to amoxicillin, 2.46% to metronidazole, 18.94% isolates to amikacin, 1.07% to novobiocin, 21.57% to ciprofloxacin, 31.88% isolates to levofloxacin, 31.88% to lincomycin and 22.90% isolates were sensitive to clarithromycin.

Conclusion: The results showed that clarithromycin, levofloxacin, ciprofloxacin and moxifloxacin were sensitive while Amikacin and clavulanic acid/ amoxicillin showed intermediate resistance and novobiocin, amoxil and metronidazole, were resistant to H. pylori.

Key Words: H. pylori, Gram negative bacterium, Antibiotic susceptibility test, Dyspepsia.

Citation of article: Tariq S, Imtiaz F, Akbar T, Ahmed B, Saeed S, Ansari BA. Antibiotic Resistance
Profile of Helicobacter Pylori Isolates from Dyspeptic Patients of Civil Hospital, Khairpur. Med Forum 2021;32(12):152-155.