Analysis of Microbiology and Antibiotic Susceptibility for Spontaneous Bacterial Peritonitis in Hepatitis C Positive and Non Positive Patients

Shehzeen Fatima¹, Arifa Zia Hashmi¹, Sehar Shamshad Ali¹, Kanwar Sajid Ali¹, Muhammad Umar Ali Khan¹ and Amjad Ali²

ABSTRACT

Objective: To analyze microbiology and antibiotic susceptibility of bacterial peritonitis in hospitalized patients with or without hepatitis C.

Study Design: Cross-sectional observational study

Place and Duration of Study: This study was conducted at the Pathology department of Bakhtawar Amin Medical & Dental College, Multan, from January to December 2023.

Methods: This study was included 114 observed patients (51 of them were hepatitis C positive), who underwent ascitic fluid specimen analysis through broth culture, agar culture, and blood culture mediums under aseptic conditions to assess bacterial growth, Gram staining, biochemical properties, and antibiotic susceptibility.

Results: Antibiotics sensitivity profile was tested to isolated bacterial species and results was shown in table. I. it was seen that C. freundii, Enterobacter spp, K. aerogenes, P. aeruginosa, S. aureus, S. epidermidis, S. marcescens, Salmonella spp, and shigella spp were the multidrug resistant. A. israelii and E. coli was the most sensitive against antibiotics. Presence of bacterial isolates from ascitic fluid was shown in figure. I. E. coli, salmonella spp and shigella spp was the most common bacterial isolates identified by ascitic fluid.

Conclusion: Gram-positive and Gram-negative MDR bacteria were common causes of SBP in patients with and without Hepatitis C. Eleven bacterial species were isolated, including C. freundii, Enterobacter spp, K. aerogenes, P. aeruginosa, S. aureus, S. epidermidis, S. marcescens, Salmonella spp, and Shigella spp, all multidrug-resistant. A. israelii and E. coli were most sensitive to antibiotics. Meropenem, a broad-spectrum beta-lactam antibiotic, showed the best results against various MDR bacterial isolates.

Key Words: Bacterial peritonitis, Antibiotic susceptibility, Hepatitis C, Microbiology

Citation of article: Fatima S, Hashmi AZ, Ali SS, Ali KS, Khan MUA, Ali A. Analysis of Microbiology and Antibiotic Susceptibility for Spontaneous Bacterial Peritonitis in Hepatitis C Positive and Non Positive Patients. Med Forum 2024;35(11):165-168. doi:10.60110/medforum.351135.