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32.Investigating the Role of Epigenetics in the Development of Neurological Disorders Developing Novel Therapies for Alzheimer’s Disease
Arsalan Ahmed Uqaili1, Rabia Uqaili2, Saima Naz Shaikh1, Komal Siddiqui3, Hira Saeed Khan4 and Moomal Tagar1
ABSTRACT
Objective: This study investigated the emerging field of epigenetics and its possible implications for AD.
Study Design: Cross-sectional study
Place and Duration of Study: This study was conducted at the Liaquat University of Medical and Health Sciences, Jamshoro, Sindh from 10 December 2021 to 10 May 2022.
Materials and Methods: We investigated the role of epigenetic alterations, like DNA methylation, histone modification, and miRNA expression, in pathogenesis of AD using in vitro studies, animal models, and human cohort analyses.
Results: Our findings emphasized the complexity and dynamic nature of epigenetic changes in genes associated with Alzheimer's disease, such as Amyloid Precursor Protein, Presenilin 1, Presenilin 2 and Apolipoprotein E. Although precise causal relationship between these alterations and AD has yet to be determined, the observed alterations provided valuable insights into potential therapeutic targets. Due to the limited efficacy and significant adverse effects of current medications, we discussed the need for novel treatment strategies. By targeting epigenetic modifications, we believe it is possible to develop innovative and more effective treatments for Alzheimer's disease.
Conclusion: Our findings contributed to growing understanding for epigenetic landscape of Alzheimer's disease and encourage further investigation of epigenetic mechanisms as Forthcoming Avenue for AD research and treatment development.
Key Words: Epigenetics; Histones; miRNA expression; Molecular switches.