31. The Apolipoprotein-B/ Apolipoprotein-A1 Ratio in Normal Individuals Verses Patients with Metabolic Syndrome in Tertiary Care Units of District Peshawar, KPK
Naila Anjum1, Ayesha Jamil1, Nizamuddin1, Arshad Parvez2 and Abida Yasmin1
ABSTRACT
Objective: The main objective of the study was to determine the ratio of Apo-B/Apo-A1 in normal individuals and patients with metabolic syndrome.
Study Design: Comparative / case control study.
Place and Duration of Study: This study was conducted at the Department of Pharmacology, KGMC, Peshawar from June 2015 to December 2015.
Materials and Methods: Total of 200-cases, including 150-Met-S and 50-controls were enrolled in different tertiary care hospitals of Peshawar. After formal consent, detail history and clinical examination, data was collected about height, weight, socioeconomic condition, blood pressure and waist circumference and diagnosis of Met-S was made accordingly. Blood glucose levels, Apo-B and Apo-A1 and lipid profile was done in all patients and normal individual.
Results: Among 200-study population, 150 were cases having Met-S, while 50 were normal control. The mean age was 47.75±4.79 years in patients, while it was 45.16±3.84 years in control group. In both cases and control groups, male-female ratio was 61/89 and 32/18 respectively. The ratio of Apo-B/Apo-A1 was calculated to measure the relative risk for coronary heart disease. The study showed ½ average risks in subjects with Met-S, was 4.9% in males and 1.1% in females. In control, it was 3.1% in males and 5.5% in females. In my study majority of the cases in both Met-S (68.8% male, 70.7% female) and controls (96.8% male & 88.8% female) fall in twice-average risk category group. There was threefold risk in Met-S patients was 26.2% in male and 28% in female. No such association was found in the controls.
Conclusion. It is concluded from the study that ratio of Apo-B/Apo-A1 can be used as one of the best variable to quantitate the risk of coronary heart disease in normal individuals and patients with metabolic syndrome.
Key Words: Metabolic Syndrome (Met-S), Apolipoprotein, And Coronary Heart Disease.
Citation of article: Anjum N, Jamil A, Nizamuddin, Parvez A, Yasmin A. The Apolipoprotein-B/ Apolipoprotein-A1 Ratio in Normal Individuals Verses Patients with Metabolic Syndrome in Tertiary Care Units of District Peshawar, KPK. Med Forum 2017;28(3):123-127.