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30.A Prospective Study of the Effectiveness of Triple Therapy in the Eradication of H Pylori
Naeem Jan1, Muhammad Imran Ullah3, Sadia Anjum4, Farooque Islam3, Ayesha Gulalai Marwat3 and Itizaz Hayat2
ABSTRACT
Objective: To determine the efficacy of triple therapy in eradicating H pylori in a sample of 100 patients at the gastrointestinal department of the Hospital Medical Center in Peshawar, researchers must examine the adverse effects of triple therapy and the potential risk factors that may contribute to the failure of H pylori eradication.
Study Design: A Prospective Study
Place and Duration of Study: This study was conducted at the Department of Gastroenterology (HMC), from February 2020 to February 2021.
Materials and Methods: It included a total of 100 adult patients who had been diagnosed with H pylori infection. Each patient was given a standardized triple treatment regimen including of proton-pump inhibitors, antibiotics, and an antibacterial drug. The efficacy of the treatment was assessed using 13C-derecho breath samples (UBT). We obtained and evaluated demographic, clinical, and laboratory data in addition to evaluating the patient's medical records.
Results: The H pylori infection was successfully treated by the triple therapy in 77 patients, whereas 23 patients experienced failure. There were no observable negative effects from the triple treatment.
Conclusion: The outcomes of this research show that triple therapy is a safe and efficient treatment for H pylori eradication in adult patients. As a result, it may be suggested as a first-line therapy for people with H pylori infection.
Key Words: Helicobacter pylori, Triple therapy, Eradication, Proton pump inhibitor, Antibiotics, 13C UBT, Adverse effects