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Effectiveness of Del Nido Cardioplegia on Post Cardiac Surgery Ventricular Arrhythmias

Waqas Hamid, Muhammad Ali Khan and Barira Ahmad

ABSTRACT

Objective: To evaluate the effectiveness of DNC cardioplegia as a prophylactic treatment for ventricular arrhythmias associated with cardiovascular surgery in adults.

Study Design: Cross sectional observational study

Place and Duration of Study: This study was conducted at the cardiac surgery department of Chaudhary Pervaiz Elahi Institute of cardiology, Multan from December 2019 to June 2024.

Methods: Study was started after approval from hospital ethical committee. Baseline characteristics, including age, medical history, APACHE II score, and left ventricular ejection fraction (EF), were recorded. Intraoperative data, such as surgery type, operation duration, CBP time, aortic occlusion time (AB), and cardioplegia type, were also collected. Patients were grouped by cardioplegia type. Postoperative data included maximum serum potassium, cardiac enzymes (CK, CK-MB) within 24 hours, EF within 48 hours, incidence of ventricular arrhythmia, and ICU stay length.

Results: The mean post EF% in DNC and STH groups was 61.90±5.48 and 62.40±3.75, respectively. (p=0.682). Mean CK-MB in DNC and STH group was 43.32±4.95 U/L and 33.37±7.13 U/L (p<0.001). The mean CK of the DNC and STH group was 562.30±16.76 U/L and 587.80±19.04 U/L, respectively (p<0.001). The mean length of stay of the DNC group was less than the STH group, 1.50±0.51 days and 2.47±0.50, respectively (p<0.001).

Conclusion: Del Nido cardioplegia reduces postoperative ventricular arrhythmias and preserves myocardial stability. It provides prolonged cardiac arrest with a single dose, shortening bypass time and reducing ICU stay in complex cardiac surgeries.

Key Words: Del Nido cardioplegia, Ventricular arrhythmias, Cardiac Surgery, Hospital stay, Ejection fraction

Citation of article: Hamid W, Khan MA, Ahmad B. Effectiveness of Del Nido Cardioplegia on Post Cardiac Surgery Ventricular Arrhythmias. Med Forum 2024;35(10):11-14. doi:10.60110/medforum.351003.