Evaluating the Role of Letrozole and Clomiphene Citrate in Preventing Ovarian Hyperstimulation Syndrome in Women with Polycystic Ovary Syndrome at DHQ Hospital, Mirpur, AJK

Aurooj Fatima, Hina Zubair, Sara Akram, Nasreen Akhter and
Mubashra Ghulam Muhammad

ABSTRACT

Objective: The aim of this study is to systematically investigate the relationship between vaginal microbiota composition and the recurrence of vaginal infections.

Study Design: A prospective cohort study was meticulously designed.

Place and Duration of Study: This study was conducted at the Obstetrics and Gynaecology, DHQ Hospital & Medical College, / Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, AJK from 1st June 2023 to 30th December 2023.

Methods: Participants were randomly assigned to receive either Letrozole or Clomiphene Citrate. The primary outcomes included the incidence and severity of OHSS, while secondary outcomes focused primarily on ovulation rates, pregnancy outcomes, and any associated complications.

Results: In the Letrozole group OHSS was significantly lower likened to the Clomiphene Citrate group (2% vs. 10%, p = 0.005). Severe OHSS cases were rarely reported, with only one case being reported in group of  Clomiphene and none in group of  the Letrozole. The mean severity score for OHSS was found to be lower in the Letrozole group (0.2 ± 0.6) than in the Clomiphene group (1.2 ± 1.9, p = 0.001). Most cases in the Clomiphene group were classified as mild or moderate, while no or minimal symptoms were primarily observed in the Letrozole group.

Conclusion: This study will undoubtedly contribute valuable evidence regarding the role of Clomiphene Citrate   and also Letrozole  in minimizing OHSS risk while optimizing fertility treatment outcomes for PCOS patients in the Mirpur  AJK region.

Key Words: Clomiphene Citrate, PCOS, Letrozole

Citation of article: Fatima F, Zubair H, Akram S, Akhter N, Muhammad MG. Evaluating the Role of Letrozole and Clomiphene Citrate in Preventing Ovarian Hyperstimulation Syndrome in Women with Polycystic Ovary Syndrome at DHQ Hospital, Mirpur, AJK. Med Forum 2024;35(11):136-139. doi:10.60110/medforum.351129.