29. Comparison of Efficacy of Oral and Vaginal Tablet Misoprostol for Medical Management of Missed Miscarriage
Rubina Amjad1, Kausar Parveen2, Saima Umer5, Nargis Taj2, Zohra Samreen3 and
Ashiq Hussain4
ABSTRACT
Objective: To compare the efficacy of tablet Misoprostol orally and vaginally for medical management of missed miscarriage.
Study Design: Double blind randomized clinical trial study.
Place and Duration of Study: This study was conducted at the Gynecology and Obstetrics department (Tertiary care hospital Bolan Medical College / Hospital, Quetta for 6 months since 2nd June 2019 to 2nd Dec 2019.
Materials and Methods: Total of 180 patients with clinically diagnosed of missed miscarriage and confirmed by ultrasound were included in this study. Patients were divided into two groups. The group A received tablet Misoprostol orally while group B received tablet Misoprostol vaginally.
Results:Out of 180 patients with clinically diagnosed of missed miscarriage were used. Age wise distribution shows that women of most cases were effective with Misoprostol between 21-30 years followed by 31-40 years and <=20 years in both groups.General characteristics such as mean age, gravity, parity and gestational age were not important between groups.Rate of successfully complete miscarriage was significantly high in vaginal Misoprostol patients (Group B) as compare to oral Misoprostol patients (Group A)[78.9% vs. 54.4%; p=0.001]. Stratification analysis was also performed to control effect of age and parity. Rate of successfully complete miscarriage was significantly high in vaginal Misoprostol patients (Group B) as compare to oral Misoprostol patients (Group A) for the age 21 to 30 years of age cases while below and equal to 20 as well as above 30, it was not observed significant.For primiparous and multiparous groups, successfully complete miscarriage was significant between groups while nulliparous it was not significant
Conclusion: It is concluded that Misoprostol is an effective and safe agent so it may be used for second trimester termination of pregnancy.
Key Words: Miscarriage, Misoprostol, Oral, Vaginal, Tablet.
Citation of article: Amjad R, Parveen K, Umer S, Taj N, Samreen Z, Hussain A. Comparison of Efficacy of Oral and Vaginal Tablet Misoprostol for Medical Management of Missed Miscarriage. Med Forum
2021;32(2):123-127.