28. Probiotics Accelerate the Process of Neovascularization in Wound Healing: A Comparative Study in Rats
Hina Khan1, Shagufta Memon4, Shahid Korai1, Ahmed Mujtaba Memon5, Farheen Hameed2 and Shahid Kamran3
ABSTRACT
Objective: To assess the role of probiotics in accelerating the process of Neovascularization in wound healing.
Study Design: Experimental Study
Place and Duration of Study: This study was conducted at the Al-Tibri Medical College and Hospital, during May 2018 to December 2018.
Materials and Methods: Total 18 male albino rats were selected through randomized sampling and divided into three groups; Group A was given topical normal saline, Group B was given topical probiotic (Lactobacillus Acidophilus), and Group C was given topical antibiotic. The interventional agent was given once for 21 days. Samples were taken on the 3rd, 7th, 14th, and 21st days to observe under the microscope at 400x. Data were analyzed using SPSS Version 20.0, and the mean between the groups was compared using ANOVA and post hoc Tukey's test. A P-value of ≤0.05 was considered statistically significant.
Results: Neovascularization was seen most among the group B candidates that were given topical probiotics. A significant difference (P-value ≤0.05) existed when comparing Group B with Group A and comparing Group B with Group C.
Conclusion: The results revealed the effective role of topical probiotic in accelerating the process of neovascularization, and due to their potent anti-inflammatory effects the probiotic accelerates the early availability of immune cells at site of healing and faster the process of repairing.
Key Words: Wound, Probiotic, Neovascularization, Healing
Citation of article: Khan H, Memon S, Korai S, Memon AM, Hameed F, Kamran S. Probiotics Accelerate the Process of Neovascularization in Wound Healing: A Comparative Study in Rats. Med Forum 2020;31(12):124-127.