27.Do Antioxidant Oils Help in Sustaining the Testicular Weight in Phenytoin Induced Toxicity in Rats?
Khalique-ur-Rehman1, Masood Ali2, Khalid Shehzad5, Hina Khan3, Humaira4 and
Raja Faisal3
ABSTRACT
Objective: To evaluate the effective role of anti-oxidant oils in restoring the testicular weight in phenytoin toxicity in rats.
Study Design: Experimental Study
Place and Duration of Study: This study was conducted at the Al-Tibri Medical College and Hospital, Isra University Karachi Campus from October 2019 to March 2020.
Materials and Methods: Total 32 numbers of male albino rats were randomly selected from the animal house of the institute. The animals were divided into three groups Group A induced normal diet, B given intra peritoneal injection of phenytoin, C was given corn oil and D was given virgin coconut oil. The Body weight was evaluated at the initial day and at the final day of the study. At the completion of the study the bilateral testicular weight was evaluated by using a normal digital weight scale, and compare with normal group. The data was represented in the form of Mean and compare the Mean Body weight by applying simple ‘t’ test and the testicular weight was evaluated by applying One-way ANOVA, and the level of significance was considered at P=<0.05.
Results: The study results show no significant difference was found on comparison of initial body weight with the final weight among the different groups. There was a significant different found on comparison of bilateral testicular weight of phenytoin induced toxicity group of animals as compare to other, while in virgin coconut group the animals’ testicular weight was well restoring in comparison with corn oil.
Conclusion: The study results show significant reduction of organ weight in experimental group as compare to control group, and the group of virgin coconut oil remarkably maintain the bilateral testicular weight as compare to other. Although the body weight was remains unchanged. Anti-oxidant properties of virgin coconut oil due to its biochemical composition strengthen its role against the free radicals and achieve their desirable effects on male fertility. Virgin coconut oil is easy to use and easily accessible for everyone.
Key Words: Phenytoin, Virgin Coconut Oil, Anti-oxidant
Citation of article: Rehman K, Ali M, Shehzad K, Khan H, Humaira, Faisal R. Do Antioxidant Oils Help in Sustaining the Testicular Weight in Phenytoin Induced Toxicity in Rats? Med Forum 2021;32(8):118-122.