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  3. 26. Efficacy of Tramadol Nebulizaton in Reducing Post-Operative Sore Throat
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26. Efficacy of Tramadol Nebulizaton in Reducing Post-Operative Sore Throat

Umar Iqbal1, Ahsan Khan2, Aqeel Moazzam3, Muhammad Saqib4, Asghar Ali4 and Zahid Hanif4


Objective: To compare the efficacy of preoperative tramadol nebulization versus placebo in reducing postoperative sore throat.

Study Design: Randomized controlled trial study.

Place and Duration of Study: This study was conducted at the Departments of Anesthesiology, Lahore General Hospital, Lahore and Arif Memorial Teaching affiliated with Rashid Latif Medical College Lahore from January 2018 to June 2018.

Materials and Methods: One hundred and sixty-four patients, aged 20-50 years undergoing general anesthesia. Group A was given pre-operative tramadol nebulization 1mg/kg in 3ml normal saline while Group B was given normal saline nebulization. Nalbuphine 0.1 mg per kg was used for intraoperative analgesia. After application of standard monitoring, induction was done with Propofol 2mg/kg and tracheal intubation with atracurium 0.5mg/kg. Maintenance of anesthesia was done with oxygen, nitrous and isoflurane 1.2% with IPPV. After extubation all patients were assessed after 12 hours for sore throat, hoarseness and pain (VRS score).

Results: The mean age of the patients was 38.65 ± 8.37 years in the tramadol group and 37.03+9.66 years in the placebo group (P-value = 0.311). 71.9% patients achieved efficacy of the drug in the tramadol group and 51.6% attained in the placebo group in terms of no or mild post-operative sore throat (p = 0.018).80.8% males in the tramadol group had no or mild sore throat as compared to65.8%) females.

Conclusion: Pre-operative tramadol nebulization can significantly reduce the incidence of POST as compared to placebo.

Key Words: Efficacy, Placebo, POST, Sore throat, Tramadol

Citation of article: Iqbal U, Khan A, Moazzam A, Saqib M, Ali A, Hanif Z. Efficacy of Tramadol Nebulizaton in Reducing Post-Operative Sore Throat. Med Forum 2020;31(11): 111-114.