25.Concurrent Chemo Radiation with Carboplatin and Paclitaxel versus Sequential Chemotherapy followed by Radiotherapy in Esophageal Cancer
Atique Anwer Khan, Ahmed Ijaz Masood and Muhammad Arshad
ABSTRACT
Objective: This study was conducted to compare the concurrent chemo radiation with Carboplatin and Paclitaxel and Sequential Chemotherapy followed by Radiotherapy in Esophageal Cancer patients.
Study Design: A randomized control study design
Place and Duration of Study: This study was conducted at the Oncology Department in Nishtar Medical University and Hospital Multan from Feb 2020 to Feb 2021 for a period of one year.
Materials and Methods: Total 60 participants, 30 in each treatment group were included in the study. The Patients aged between 22-75, confirmed cases of esophageal cancer were included in the study. The Patients with organ metastasis, complete obstruction, or tracheoesophageal fistula, and the ones who had lost more than 10% of their body weight or have any other primary cancer or had undergone any defined surgery were excluded from the study. Patients' baseline data related to family history, physical examination, and laboratory work-up were collected. The participants were randomly grouped into two groups Group A and Group B. Group A patients received concurrent chemo radiation therapy. Group B patients received 2 cycles of chemotherapy followed by radiotherapy the tumor response was then evaluated.
Results: Demographic variables of the patients show that the median age of the patients in Group A & B was 58 & 60 years respectively. Among Group A 24 (80%), 4 (13.3%), 1 (3.3%), 1 (3.3%) patients showed complete response, partial response, stable disease & progressive disease respectively. While among Group B patients 12 (40%) showed complete response, 7 (23.3%) showed partial response, 7 (23.3%) showed stable disease and 4 (13.3%) showed progressive disease. The resultant toxicity of treatment was assessed using RTOG scheme. More toxicity was assessed in group A participants who were treated with concurrent chemo radiation.
Conclusion: The study concluded that concurrent chemo radiation with Carboplatin and Paclitaxel provide comparatively better tumor response than sequential chemotherapy followed by Radiotherapy in Esophageal Cancer. However, besides efficacious tumor response, it is also associated with acute and delayed toxicity.
Key Words: Concurrent Chemo radiation, Esophageal cancer, Sequential chemotherapy, Radiotherapy
Citation of article: Khan AA, Masood AI, Arshad M. Concurrent Chemo radiation with Carboplatin and Paclitaxel versus Sequential Chemotherapy followed by Radiotherapy in Esophageal Cancer. Med Forum 2021;32(11):103-106.