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25.Comparison of Amoxicillin, Doxycycline and Cephalosporin Activity against Human Lower Respiratory Tract Pathogen in Cold Season at South Punjab, Pakistan
M Abbas Naqvi1, Arifa Hashmi2, Shehzeen Fatima2, Aneeqa Naz3, Rizwana Kousar4 and Muhammad Ibrahim4
ABSTRACT
Objective: To compare amoxicillin, doxycycline and cephalosporin activity against human lower respiratory tract pathogen in cold season at south Punjab, Pakistan.
Study Design: A Comparative analytical study.
Place and Duration of Study: This study was conducted at the Pathology Department of Nishtar Medical University, Multan, from October 2021 to February 2022.
Materials and Methods: The study is composed of 400 patients who was suffering from lower respiratory disorders from area of south Punjab, Pakistan, in cold season. Symptoms that have been observed in patients having lower respiratory tract infections with sputum production, tachypnea, cough, chest pain and fever were included in study. We took sputum as a sample from patients and inoculated the sample on selective media. After incubation we performed biochemical testing for the identification of bacterial specie than performed antibiotics susceptibility testing and measured the zone of inhibition of antibiotics and noted it. All data were in entered and analysed in SPSS. Mean was calculated for quantitative variables and frequencies and percentages for qualitative variables.
Results: Mean age of patients was 29.36 ± 10.21 years with 280 (70%) were male and female 120 (30%). Out of 400 samples, bacterial strains were isolated in 250 (62.5%) cases and among gram positive bacteria, we found Staphylococcus aureus (n=50, 20%) the most predominant pathogen. Among the isolated gram negative bacteria, Klebsiella pneumoniae (n=90, 36 %) was the most predominant pathogen, followed by Pseudomonas aeruginosa (n=30, 12 %) and Escherichia coli (n=35, 14 %). There were some multiple drug resistance isolates also. We found amoxicillin, the most susceptible drug against available bacterial strains, followed by doxycycline and cephalosporin.
Conclusion: In our study results amoxicillin is found more susceptible drug than doxycycline and cephalosporin against human lower respiratory tract pathogens.
Key Words: Respiratory tract infection, Bacterial infection, Antibiotics, Drug resistant.
Citation of article: Naqvi MA, Hashmi A, Fatima S, Naz N, Kousar R, Ibrahim M. Comparison of Amoxicillin, Doxycycline and Cephalosporin Activity against Human Lower Respiratory Tract Pathogen in Cold Season at South Punjab, Pakistan. Med Forum 2023;34(8):106-109.doi:10.60110/medforum.340825.