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Dilaram Khan, Fakhare Alam and Jan Dil Khan

ABSTRACT

Objective: To find the frequency of vitamin D deficiency in patients with chronic liver disease and evaluate the relationship of vitamin D deficiency with advancement in liver disease severity.

Study Design: Descriptive study

Place and Duration of Study: This study was conducted at the Department of Gastroenterology, Lady Reading Hospital, Peshawar from August 2020 to February 2021.

Materials and Methods: One hundred and forty one patients with chronic liver disease were enrolled. Vitamin D level was measured in the blood sample of patients in the hospital laboratory. The cut-off value for vitamin D deficiency was set at Serum vitamin D [25 (OH) D] level <30 nmol/L.

Results: Ninety nine patients (70.2%) were males and 42 patients (29.8%) were females. The mean age was 53.40±12.19 years. Hepatitis C was the most common underlying cause of chronic liver disease observed in 80 patients (56.7%). 83 patients (58.9%) had Child-Pugh Class C chronic liver disease. Vitamin D deficiency was observed in 95 patients (67.4%). Gender and Child-Pugh Class had a significant association with vitamin D deficiency.

Conclusion: Vitamin D deficiency is a frequently occurring finding in patients. Female patients with advanced liver fibrosis are more likely to have vitamin D deficiency.

Key Words: Vitamin D deficiency, Fibrosis, End stage liver disease

Citation of article: Khan D, Alam F, Khan JD. Vitamin D Deficiency in Patients with Chronic Liver Disease. Med Forum 2022;33(1):99-101.