24. Preventative Role of Vitamin C and Naproxen in Alcohol-Induced Liver Toxicity on the Basis of Gross Parameters: A Comparative Study in Rat Model
Raja Faisal1, Amanullah Khokhar2, Shagufta Memon5, Ghazala Panhwar3, Syed Liaquat Ali3 and Farheen Hameed4
ABSTRACT
Objective: To evaluate the preventative role of Vitamin C and Naproxen in Alcohol-induced liver toxicity by evaluating the gross parameters in albino rats.
Study Design: Experimental Study
Place and Duration of Study: This study was conducted at the Anatomy Department of Al-Tibri Medical College and hospital, Isra University Karachi Campus from Jan 2018 to Nov 2018.
Materials and Methods: 60 albino rats with equal gender distribution were selected based on the probability random sampling technique and placed in three groups of 20 again with an equal gender distribution. Group A was given only given purified Ethanol for 10 days and served as our positive control group, Group B was given Vitamin C and Naproxen Prophylaxis for 7 days after which they were intoxicated with Ethanol for 10 days, and Group C was simultaneously Administered Vitamin C, Naproxen, and Ethanol for 10 days. The initial body weight and final body weight, along with the absolute and relative liver weight of all the test subjects were recorded, and data analysis was conducted using SPSS 21.0 with P-Value ≤0.05 considered to be Statistically Significant.
Results: Group A animals experienced a weight loss; Group B did not experience a substantial weight loss, while Group C experienced a weight gain. No significant difference in body weight was seen between the three groups; however, there were significant differences in absolute and relative liver weight between all three groups. Group A rats experienced an increase in body weight, whereas the Weight of the liver in Group C animals remained constant. Conclusion: The antioxidative and anti-inflammatory effects of Vitamin C and Naproxen demonstrated hepatoprotective effects on the liver, protecting it from alcohol-induced liver injury.
Keywords: Naproxen, Prophylaxis, liver toxicity
Citation of article: Faisal R, Khokhar A, Memon S, Panhwar G, Ali SL, Hameed F. Preventative Role of Vitamin C and Naproxen in Alcohol-Induced Liver Toxicity on the Basis of Gross Parameters: A Comparative Study in Rat Model. Med Forum 2021;32(1):98-101.