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24. Morphometric Study of Mobile Phone Induced Injury to Cerebellum with Preventive Effects of Ginger in Albino Rats
Syed Alamdar Raza Zaidi1, Shabnam Khan2, Nasim Marvi2, Ashia Qamar3, Meesum Iftakair2 and Samia Khalid3
ABSTRACT
Objective: To observe the effects of radio frequency (RF) radiation generated by third generation (3G) mobile phones on the rat cerebellum and possible protection provided by ginger in alleviating this injury in albino rats.
Study Design: Prospective Experimental Study
Place and Duration of Study: This study was conducted at the Basic Medical Sciences Institute (BMSI), Jinnah postgraduate Medical Centre (JPMC) for 6 months from January 2021 to July 2021.
Materials and Methods: Twenty four adult rats were procured from the animal unit of BMSI and arranged into four groups according to the assigned treatment. Group A: control; group B: 2100MHz RF radiation generated by 3G mobile phone; Group C: RF radiation and oral ginger 250mg/kg/day and Group D: ginger only. The rats were euthanized at termination of study. Brain of rats was processed for H & E stain to record thickness of granular layer as well as diameter of Purkinje fibers and Beilschowsky stain to observe microscopic anatomy of cerebellum.
Results: There was highly significant decrease in thickness of granular layer and decreased diameter of Purkinje neurons in RF radiation treated rats in group B as compared to controls. Distortion in the morphology of Purkinje cells and decreased number of axons were observed in tissue sections from group B animals as compared to control. These findings improved to a pronounced extent in group C animals who were given ginger concomitant to RF radiation by mobile phones.
Conclusion: The cerebellum of rat brain is sensitive to damage by radiofrequency radiations emitted by cell phones. However, ginger minimizes these damaging effects when used simultaneously.
Key Words: Radiofrequency radiation, Brain, Cerebellum, Ginger, Microscopic Anatomy
Citation of article: Zaidi SAR, Khan S, Marvi N, Qamar A, Iftakair M, Khalid S. Morphometric Study of Mobile Phone Induced Injury to Cerebellum with Preventive Effects of Ginger in Albino Rats. Med Forum 2022;33(8):110-114.