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  3. 24. Comparing the Efficacy of Standard Triple Therapy with Proton Pump Inhibitor and Vonoprazan and Amoxicillin Dual Therapy for Helicobacter Pylori Eradication
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24. Comparing the Efficacy of Standard Triple Therapy with Proton Pump Inhibitor and Vonoprazan and Amoxicillin Dual Therapy for Helicobacter Pylori Eradication

Muhammad Mumtaz Ather1, Muhammad Tahir2, Talha Rasheeq2, Shahid Mukhtar3, Aamena Gardazi3 and Muhammad Ibrahim4

ABSTRACT

Objective: To compare the effectiveness of dual therapy with amoxicillin plus vonoprazan and standard triple therapy with amoxicillin, clarithromycin and proton pump inhibitor in terms of H Pylori eradication.

Study Design: Randomized controlled trial study

Place and Duration of Study: This study was conducted at the Department of gastroenterology in Bakhtawar Amin Medical & Dental College, Multan, from October 2021 to September 2022.

Materials and Methods: A total of 84 patients diagnosed as positive for Helicobacter Pylori infection through stool antigen test. Grouping of patients was done by lottery method in group A and B. In group A Vonoprazan and amoxicillin was given and in group B Amoxicillin with clarithromycin and proton pump inhibitor (PPI) were given. Main variables of study were Stool antigen (positive/negative), Bloating, diarrhea and nausea vomiting. SPSS version 24 was used for data analysis.

Results: The average age of Group A and Group B was 39.12±3.22 years and 38.51±2.84 years respectively. Male proportion is higher in both groups. In Group A, 71.4% patients had negative HP stool Ag and 59.5% patients had negative HP stool Ag, in Group B. (p>0.050). The prevalence of diarrhea, nausea vomiting and bloating in both the groups were 14.3% vs. 9.5%, 16.7% vs. 14.3% and 16.7% vs. 2.4 respectively (p>0.050).

Conclusion: Vonoprazan and amoxicillin dual therapy is better as compare to conventional triple therapy for h pylori eradication. In this era of rapidly developing antibiotic resistance, use of Vonoprazan based dual therapy for h pylori eradication is potentially new 1st line treatment.

Key Words: Helicobacter Pylori, Proton Pump Inhibitors, Amoxicillin, Clarithromycin, Vonoprazan

Citation of article: Ather MM, Tahir M, Rasheeq T, Mukhtar S, Gardazi A, Ibrahim M. Comparing the Efficacy of Standard Triple Therapy with Proton Pump Inhibitor and Vonoprazan and Amoxicillin Dual Therapy for Helicobacter Pylori Eradication. Med Forum 2022;33(12):101-104.