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  3. 23. Positive Predictive Value of Shear Wave Elastography in Predicting the Stage of Liver Fibrosis Taking Histopathology as Gold Standard
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23. Positive Predictive Value of Shear Wave Elastography in Predicting the Stage of Liver Fibrosis Taking Histopathology as Gold Standard

Rabia Asif, Amber Goraya and Abid Ali Qureshi

ABSTRACT

Objective: The objective of this study was to determine the positive predictive value of shear wave elastography (SWE) in predicting the stage 3 of liver fibrosis taking histopathology as gold standard.

Study Design: A cross-sectional study.

Place and Duration of Study: This study was conducted at the Research was conducted at Department of Diagnostic Radiology, Children Hospital Lahore, from April, 2019 to October, 2019.

Materials and Methods: This study involved 117 children of both genders aged between 1 to 15 years having chronic liver disease. Ultrasound abdomen was performed and stage 3 fibrosis was diagnosed on shear wave elastography (7.1-12.0 kPa). The diagnosis was later confirmed on histopathology of liver tissue. Diagnosis of histopathology was taken as gold standard and results of SWE on ultrasound were judged accordingly as true positive or false positive.

Results: The mean age of the children was 8.4±4.4 years while the mean weight was 32.1±14.9 Kg. There were 74

(63.2%) male and 43 (36.8%) female children. Histopathology confirmed diagnosis of Stage-3 liver fibrosis in 107 (91.5%) cases. Taking histopathological diagnosis of stage-3 liver fibrosis as gold standard, there were 107 (91.5%) true positive and 10 (8.5%) false positive cases. It yielded a positive predictive value of 91.5% for SWE on ultrasound in predicting stage 3 of liver fibrosis taking histopathology as gold standard. Similar positive predictive value was noted across various subgroups of children based on age (p-value=0.998), gender (p-value=0.824) and weight (p-value=0.969).

Conclusion: The positive predictive value of shear wave elastography on ultrasound was found to be 91.5% in predicting stage 3 hepatic fibrosis taking histopathology of liver tissue as gold standard. Key Words: Hepatic Fibrosis, Ultrasound, Shear Wave Elastography, Positive Predictive Value

Citation of article: Asif R, Goraya A, Qureshi AA. Positive Predictive Value of Shear Wave 

Elastography in Predicting the Stage of Liver Fibrosis Taking Histopathology as Gold Standard. Med Forum

 

2021;32(2):98-101.