Abdul Saboor Soomoro¹, Sultan Mohammad Tareen² and Mian Azhar Ahmad³

ABSTRACT

Objective: To investigate better clinical success with combination regime of doxazosin, finasteride or when either of the two drugs used as monotherapy on benign prostatic hyperplasia.

Study Design: Descriptive / cross sectional study.

Place and Duration of Study: This study was conducted at the DHQ Hospital Sahiwal & Ghulam Muhammad Mahar Medical College & Teaching Hospital Sukkur from January 2014 to March 2016.

Materials and Methods: This descriptive cross sectional study was done on 3000 patients with symptomatic BPH (benign prostatic hyperplasia). Amongst them, initial 100 patients were recruited for pilot study and 2900 patients were involved in the full-scale study. Total number of patients was divided into four groups, placebo, patients taking doxazosin, monothery with finasteride, combination therapy group. Medication was classed into two groups; first group drugs with potential clinical benefits, second group comprised ‘placebo’ drugs, mimicked shape wise and taste similar to doxazosin or finasteride.

Results: After a follow up 1 to 3 years, in all men of more than fifty years coming with signs and symtoms specific for BPH where surgery was not the consideration, the highest incidence of successful clinical outcomes were noted with patients taking combination regime of Doxazosin, Finasteride on benign prostatic hyperplasia.

Conclusion: Successful clinical outcomes were achieved in our research work when combination regime of Doxazosin, Finasteride on benign prostatic hyperplasia were used, rather than when either of the two drugs were used as monotherapy

Key Words:  Doxazosin, Finasteride, Benign prostatic hyperplasia

Citation of article: Soomoro AS, Tareen SM, Ahmad MA. Comparative Study of Clinical Outcomes of

Monotherapy and Combination Regime of Doxazosin, Finasteride on Benign Prostatic Hyperplasia in