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22.The Efficacy of Oral Metronidazole in Reducing Pain Post-Hemorrhoidectomy: A Randomized Controlled Trial Sidra Munawar, Maria Zafar, Muhammad Azhar, Muhammad Ali, Sadia and Huda Ali ABSTR
Sidra Munawar, Maria Zafar, Muhammad Azhar, Muhammad Ali, Sadia and
Huda Ali
ABSTRACT
Objective: The study aims to compare the effect of oral metronidazole and placebo on the mean pain score of patients post-hemorrhoidectomy.
Study Design: A randomized controlled trial study.
Place and Duration of Study: This study was conducted at the POF Hospital, Wah Cantt, between 21st March and 21st September, 2019.
Materials and Methods: Patients with grade III and IV hemorrhoids on whom hemorrhoidectomy was performed were included in the study. Patients in the experimental group were given oral metronidazole 500 mg every eight hours for seven days, while the control group received a placebo. Patients’ pain was assessed through visual analogue scores (VAS) on the seventh post-operative day. Data was recorded in a predesigned proforma.
Results: The VAS score post hemorrhoidectomy was significantly less in the experimental group (3.59 ± 0.55) compared to the control (6.13 ± 1.04).
Conclusion: Since bacterial colonization is inevitable after hemorrhoidectomy, metronidazole can help reduce post-operative pain by reducing bacterial proliferation and inflammation of the surgical site.
Key Words: Hemorrhoids, hemorrhoidectomy, metronidazole, pain score, Flagyl.