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Naveed Khan¹, Muhammad Abbas¹, Hameed Ullah¹ and Subhanuddin³

ABSTRACT

Objective: To study hematological changes in typhoid fever.

Study Design: Observational study

Place and Duration of Study: This study was conducted at the pathology department of Bacha Khan Medical College Mardan and Medical Department of Mardan Medical Complex Teaching Hospital Mardan from June, 2015 to February, 2016.

Materials and Methods: This study included total of 100 patients of typhoid fever and 50 as a control healthy individuals. Typhoid positive serum was taken as that with visible agglutination at 1:32O. To exclude false positive we used rising titer for widal test. These patients were also Typhidot positive and were having step ladder rising of fever. Complete blood counts were performed by hematology analyzer an automated machine (Sismex Japan)

Results: In the present study 40% had anemia, Hemoglobin level was 9.1±.879 g/dl, 20% had thrombocytopenia, platelet count was 120 ±17.897 x10³/ul, 30% had leucopenia, total leucocyte count was 2.8 ± 1.557 x 10³/ul and 6% patients showed leucocytosis, total leucocytecount was 14.5± 1.875 x 10³/ul. Hemoglobin, white blood cell and platelet count were significantly lowered as compared to control group.

Conclusion: The study concluded that hematological abnormalities are significant findings in typhoid fever. Any patient presenting with cytopeneia should be strictly screened for Typhoid fever to avoid unnecessary use of bone marrow aspiration. Moreover full blood counts should be performed on these patients as this gives useful information to the clinician for effective and prompt treatment. Due to high morbidity and mortality in misdiagnosed cases further research work and new diagnostic tests are recommended for diagnosis of the disease Key Words: Anemia, Typhoid fever, Thrombocytopenia, Leucopenia.

Citation of articles: Khan N, Abbas M, Ullah H, Subhanuddin, Manzoor. Hematological Changes in Patients Presenting with Typhoid Fever. Med Forum 2017;28(9):87-90.