22. Anti-Inflammatory Effect of Local Application of Curcuma Gel in Patients of Chronic Periodontitis
Iqra Amin1, Asrar Ahmed2, Amna Amanat2, Faiqua Yasser3, Muhammad Dilshad1 and Muhammad Sharjeel Ilyas4
Objective: To determine the anti-inflammatory effects of oral curcuma gel on salivary calprotectin level in patients of chronic periodontitis.
Study Design: Randomized controlled clinical trial study.
Place and Duration of Study: This study was conducted at the Department of Periodontology, de’ Montmorency College of Dentistry (Punjab Dental Hospital) Lahore from February 2019 to August 2019.
Materials and Methods: In this experimental study 15 patients were selected having chronic periodontitis and pocket depth 3-7mm. Subgingival ultrasonic scaling was done of patients at day 0 after collection of saliva and Pocket depth (PD) measurement. Patients were instructed to apply curcuma oral gel (each gram containing 10 mg of curcuma longa extract and glycerol is used as a vehicle), twice a day for three weeks after brushing. Pocket depth (PD) measured and saliva was collected 3 times during the study – Day 0, Day 10 and at day 21 with ±2 days of arrival. The calprotectin levels will be measured in saliva and compared each time by ELISA technique according to manufacturer’s instructions.
Results: In this study, curcuma oral gel treatment proves to be effective in terms of PD measured and calprotectin levels in saliva. Marked reduction in PD from 5.27±0.78 at day 0 to 3.17±0.41 at day 21 has been measured having p-value < 0.001. Mean calprotectin level at day 0 is 3.75±0.64 and at day 21 is 1.67±0.32.
Conclusion: This study shows effectiveness of curcumin in curing periodontitis by reducing proteomes present in saliva. The anti-inflammatory action of Curcuma gel topical application is proved clinically by the values of PD measured and biochemically by reduction in salivary calprotectin level.
Key Words: Saliva, Calprotectin level, Periodontitis, Curcuma gel
Citation of article: Amin I, Ahmed A, Amanat A, Yasser F, Dilshad M, Ilyas MS. Anti-Inflammatory Effect of Local Application of Curcuma Gel in Patients of Chronic Periodontitis. Med Forum 2020;31(11): 95-98.