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Maryam R Tarar¹, Tahir Naeem², Nusrat Alavi³, Urfa Shafi¹, Aneela Khawaja² and
Asma Ejaz²

ABSTRACT

Objective: To determine the significance of ADA activity in combination with differential cell count (WBC) and other biochemical variables (Lactate dehydrogenase (LDH), Erythrocyte sedimentation rate (ESR), Proteins).

Study Design: descriptive cross-sectional study

Place and Duration of Study: This study was conducted at the Pathology department of Shalamar Teaching Hospital, Lahore from March, 2017 till February, 2020.

Materials and Methods: A total of 352 samples from patients of all ages and both genders were included in which either pleural, ascetic or other sterile body fluids (3cc each) were examined. ADA level of ≥ 40 units/mL was deemed suggestive of TB and measured by the spectrophotometric method.

Results: Among 352 patients, the mean age was 51.9±18, with equal male female ratio. ADA level ≥ 40 units/mL was noticed in 35.51% samples. Positive correlation of ADA with LDH (.472), ESR (.195) and WBC (.240). Positive correlation of LDH with lymphocytes (.194) and Negative correlation with polymorph leucocytes (-.190). Lymphocytic Neutrophil ratio was 0.19 with SD of 24.5.

Conclusion: Tuberculosis is the widespread infectious disease especially in low-income and under-developed countries. In tuberculous pleuritis ADA level of ≥ 40 U/mL in lymphocyte-predominant effusions makes the identification of tubercle bacilli more credible. This method shows positive correlation of ADA with other biochemical factors as well. This efficient test is easy to perform with rapid turnaround time for diagnosis of tuberculosis.

Key Words: Adenosine deaminase enzyme (ADA), Lactate dehydrogenase enzyme (LDH), Tuberculosis.

Citation of article: Tarar MR, Naeem T, Alavi N, Shafi U, Khawaja A, Ejaz A. The Significance of ADA Level among the Suspected Tuberculosis Cases, Experience at a Tertiary Care Teaching Hospital, Lahore. Med Forum 2022;33(4):85-88.